Phenothiazines

Phenothiazines are divided into three groups. These are aliphatic, piperazine, and piperidine. Each category has different side effects (see Table 15-2). The aliphatic group produces a strong sedative effect, decreases blood pressure, and may moderate extrapyramidal symptoms (EPS). Chlorpromazine is a member of this group.

The piperzine group produces a low sedative effect and a strong antiemetic effect, more EPS, and little effect on blood pressure. Included in this group are prochlorperazine (Compazine), fluphenazine (Prolixin), perphenazine (Trilafon), and trifluoperazine (Stelazine).

The piperidine group includes mesoridazine besylate (Serentil) and thioridazine HCl (Mellaril). These produce few EPS or anti-emetic effects and can cause hypotension.

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