Narcotic Agonistantagonists

A narcotic agonist-antagonist (agonist) is an opioid narcotic mixed with nal-oxione (antagonist) to try to curb a form of drug misuse. Although the exact mechanism of action is unknown, these agents have both agonist and antagonist effects on the opioid receptors. Generally, these drugs are less potent and have a

Other Narcotic Analgesics of the Opium and Synthetic Group

Drug

Purpose

Codeine (sulfate, phosphate), CSS II

For mild to moderate pain

Hydromorphone HCl (Dilaudid) CSS II

For severe pain

Levorphanol tartrate (Levo-Dromoran) CSS II

For moderate to severe pain

Meperidine (Demerol) Synthetic narcotic CSS II

For moderate pain

Fentanyl (Duragesic, Sublimaze) CSS II

Short-acting potent—used with short-term surgery; patches for controlling chronic pain

Sufentanil (Duragesic, Sublimaze) CSS II

Short-acting potent—used as part of balanced anesthesia

Methadone (Dolophine)

Similar to morphine but longer duration of action; used in drug abuse programs

lower dependency potential than opioids and withdrawal symptoms are not as severe. Commonly used narcotic agonist-antagonists are Pentazocine (Talwin), Butorphanol tartrate (Stadol), duprenorphine (Buprenex), and nalbuphine hydrochloride (Nubain). Their pharmacokinetics, adverse, and side effects are similar to morphine.

See Narcotic Agonist-Antagonists listed in the Appendix. Detailed tables show doses, recommendations, expectations, side effects, contraindications, and more; available on the book's Web site (see URL in Appendix).

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