Fluoroquinolones and Drug Drug Interactions

If ciprofloxacin, a member of the fluoroquinolones family, is prescribed, then it should be given two hours before the patient is given antacids, ferrous sulfate, or sucralfate because these medications lower the absorption of ciprofloxacin.

Patients who are taking theophylline or other xanthines with fluoro-quinolones should be aware that the theophylline plasma levels can rise leading to toxicity.

If the patient takes fluoroquinolones while also taking warfarin, the anticoagulant effect of warfarin increases and could result in bleeding. The prothrombin time (PT) should be monitored if both are administered together.

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