Most Effective Polycystic Ovarian Syndrome Treatment

The Natural Pcos Diet

The Natural Pcos Diet, By Jenny Blondel, A Leading Australian Naturopath In Response To Thousands Of Requests For Professional Information To Help Women Suffering From Pcos. Real Solutions To Naturally Overcome PCOS. Naturally balance your hormones Increase your chances of conceiving Help you lose weight and feel good Curb your cravings for sugary foods Turn your fatigue around Achieve clearer, glowing skin See improvements in your mood. Do You Feel PCOS Is. Ruling Your Life? At Last! The Natural PCOS Diet. A Naturopath’s Easy Step-by-Step Guide to Overcoming PCOS Is. Now Available! More here...

The Natural Pcos Diet Summary


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Thiazolidinediones in Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is characterized by menstrual irregularities, infertility, hyperandro-genism, obesity, and insulin resistance. In a study of rosiglitazone (4 mg twice daily for 2 months) with or without clomiphene in 25 women with PCOS who had not responded to clomiphene alone, ovulatory rates were higher in the combined versus monotherapy groups (77 and 33 , respectively) 53 . Pioglitazone has also been shown to improve ovulation rates and hyperadrogenism associated with PCOS. In a randomized controlled trial 54 , 40 women were assigned to receive 30 mg piogli-tazone versus placebo for 3 months. The results revealed that the pioglitazone group had a significant decrease in their free androgen index as well as higher ovulation rates (41 had normal ovulation in the pioglitazone group as compared with 5.6 in the placebo group). These results point to an exciting new treatment option for PCOS however, because of the effects of these agents on gene expression, there may...

Risk Factors For Obesity

Various medical genetic causes of obesity must also be considered. Endocrine conditions associated with weight gain include hypothyroidism, Cushing's syndrome, hypogonadism in the male, polycystic ovary syndrome (PCOS) in the female and growth hormone deficiency (42). Rare genetic causes of obesity include Prader-Willi syndrome, Bardet-Biedl syndrome and Cohen's syndrome. Diabetes can be an obvious consequence of the severe obesity associated with such syndromes.

Pharmacological Interventions

With which this term is applied to metformin, in the absence of weight loss, insulin-stimulated glucose disposal does not increase in metformin-treated individuals 59-61 . It is outside the province of this chapter to discuss the mechanism of action of met-formin, nor its use as an effective treatment of type 2 diabetes or PCOS, but the clinical utility of metformin does not seem to reside in its ability to enhance insulin-stimulated glucose uptake. In addition to their clinically useful metabolic benefits, TZD compounds are approved for treatment of type 2 diabetes, and have been shown to decrease hepatic steatosis in patients with nonalcoholic fatty liver disease 65 and result in pregnancy when given to women with PCOS 66 . In light of this appealing clinical profile, the possibility that these compounds might be particularly effective in reducing CVD, and preventing the development of type 2 diabetes in particularly susceptible individuals, that is, insulin resistant, but without...

Lawrence P Reynolds Anna T Grazul Bilska and Dale A Redmer

The microvasculature of the ovary is relatively unique in several respects, which we will explore in this chapter. However, beyond its uniqueness, which makes studying it interesting and informative in and of itself, the ovarian microvasculature is important for practical reasons as well. Among these reasons is the fact that the ovary not only is critical to normal reproductive function but also is the site of several major pathologies, including ovarian hyperstimulation syndrome, polycystic ovary syndrome, and ovarian carcinoma. In addition, ovarian follicles and corpora lutea are some of the most rapidly growing and most vascular tissues known, and therefore they can serve as outstanding models for understanding the regulation of normal microvascular growth, development, and function. This is extremely important because as Hudlicka pointed out, There are numerous accounts of capillary growth in developing organisms or under pathological conditions, but very little is known about...

Physical examination

Hair distribution may reveal signs of androgen excess. The absence of both axillary and pubic hair in a phenotypically normal female suggests androgen insensitivity. 4. External genitalia and vagina should be inspected for atrophy from estrogen deficiency or clitoromegaly from androgen excess. An imperforate hymen or vaginal septum can block the outflow tract.

Antiepileptic drug therapy Drug interactions

Once the diagnosis of epilepsy has been made, the decision must be made as to whether antiepileptic medication is needed or not. If it is, the most appropriate antiepileptic drug is to be selected. The choice of antiepileptic medication depends primarily on an accurate classification of the seizure type and or epilepsy syndrome. Although the old antiepileptic drugs such as phenobarbitone and phenytoin were effective in controlling seizures, they had such frequent and severe adverse effects during long-term use in patients with mental retardation that they cannot now be recommended as drugs of first choice if other options are available. If newer drugs are not available, phenobarbitone, primidone, and phenytoin may be used with caution, if special attention is paid not only to control of seizures, but also to behavioural, cognitive, and cerebellar functions which may be affected adversely, and sometimes insidiously, by these drugs. Although the experience on the use of the new...

Angiogenesis in the Ovary

As mentioned earlier, a variety of pathologies of the female reproductive organs are associated with disturbances of the angiogenic process, including ovarian hyperstimulation syndrome, ovarian carcinoma, and polycystic ovary syndrome. These pathologies also are associated with altered expression of VEGFs and or FGFs. These pathologies of the female reproductive organs represent major socioeconomic problems. For example, ovarian carcinoma often shows a poor prognosis and low survival rate and therefore is recognized as one of the most dangerous cancers in female patients. In fact, ovarian, uterine, and cervical cancers represent approximately 13 percent of new cases of cancer and 10 percent of cancer deaths in the United States, making these the fourth-leading cause of deaths due to cancer in women. In the near future, angiogenic or antiangio-genic compounds may prove to be effective therapeutic agents for treating these pathologies. In addition, monitoring of angiogenesis or...

Insulin Resistance Hyperinsulinemia and the IRS

Pathogenesis of the abnormalities and clinical syndromes that make up the IRS. To begin with, type 2 diabetes is the only clinical syndrome listed in Table 3 that is not associated with a significant degree of hyperinsulinemia. Obviously, in this instance, it is the failure of the pancreatic P-cell to adequately compensate for the insulin resistance that is responsible for the development of the clinical syndrome 16 . In the case of the other abnormalities and clinical syndromes listed in Tables 2 and 3, it is the relationship between insulin resistance, compensatory hyperinsulinemia, and the individual tissue response to the chronically elevated plasma insulin concentrations that is responsible for the observed pathophysiology. In this context, it is necessary to address the question of differential tissue insulin sensitivity, for if this phenomenon did not exist, there would be no IRS. For example, the ability of insulin to stimulate muscle glucose uptake and inhibit free fatty acid...

Trends in the Use of Antidiabetic Drugs

Use of drugs to prevent diabetes or to treat related diagnoses (e.g. polycystic ovary syndrome) may result in changes in prescription patterns in the future. Such changes may confound the interpretation of data on drug use. At present there is some evidence for the efficacy of metformin, troglita-zone (now withdrawn), orlistat, rosiglitazone and rimonabant 17-19 on delaying the development from impaired glucose tolerance to diabetes. However, use of these drugs to prevent diabetes is not currently recommended.

Weight Loss

It has been clear for more than 30 years that overweight obese individuals are more likely to be insulin-resistant hyperinsulinemic, and that weight loss in these individuals will improve insulin sensitivity, associated with lower plasma insulin concentrations and an improved lipoprotein phenotype 39 . It is now well-recognized that a variety of metabolic abnormalities improve when overweight obese individuals lose weight, and that this intervention can lead to substantial clinical benefit. For example, it has been shown that weight loss leads to clinical improvement in patients with essential hypertension 40 , PCOS 41 , and nonalcoholic fatty liver disease 42 . Of greater relevance to this book is the finding that weight loss, in association


An enormous amount of new information relevant to the role of insulin resistance in human disease had appeared since the introduction of the concept of Syndrome X, and the abnormalities related to insulin resistance have broadened considerably. At the same time, it has become clear that the adverse clinical outcomes associated with insulin resistance extend far beyond type 2 diabetes and CVD. For example, in addition to type 2 diabetes and CVD, insulin-resistant individuals are at increased risk to develop essential hypertension, PCOS, nonalcoholic fatty liver disease, congestive heart failure,


Metformin works best in patients with significant hyperglycemia and is often considered first-line therapy in the treatment of mild to moderate type II overweight diabetics who demonstrate insulin resistance. The United Kingdom Prospective Diabetes Study demonstrated a marked reduction in cardiovascular comor-bidities and diabetic complications in metformin-treated individuals. Metformin has also been used to treat hirsutism in individuals with polycystic ovarian syndrome and may enhance fertility in these women, perhaps by decreasing androgen levels and enhancing insulin sensitivity.


By definition, antiandrogens are substances that prevent or depress the action of male hormones in their target organs. Potential sites of action include go-nadotropin suppression, inhibition of androgen synthesis, and androgen receptor blockade. Compounds that affect each of these sites are available. Potential clinical uses of antiandrogens include suppression of androgen excess and treatment of androgen-dependent tumors. Extreme clinical examples of androgen excess include central precocious puberty, the adrenogenital syndromes, and androgen-secreting adrenal, ovarian, or testicular tumors. Less severe problems include idio-pathic hirsutism, premenstrual syndrome, and severe cystic acne.

Diabetes Mellitus

Insulin resistance also has been associated with a number of hormonal and metabolic states, including Cushing's syndrome (excessive corticosteroids), acromegaly (excessive growth hormone), and gestational diabetes. Physiological or psychological stress also can contribute to insulin resistance. Gestational diabetes mellitus is a condition that develops during the second trimester of pregnancy the cause may be rises in human placental lactogen and other hormones that contribute to insulin resistance.This condition usually resolves during the postpartum period. Another relatively common form of insulin resistance is often seen in women with polycystic ovarian syndrome, a disorder that is associated with hyperandrogenism, hirsutism, menstrual irregularities, obesity, and infertility.

Hormonal Effects

Of testosterone are likely to predispose to OSA as well. Exogenous testosterone administration to one female was reported to precipitate clinically significant OSA (48). Additionally, women with polycystic ovarian syndrome, which is characterized by ovarian failure, obesity, and androgen excess, have a higher AHI than healthy women controls (22.5 vs. 6.7 events hour) (49).

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