Relaxed

Inactive

Ca2+T

Active

Inactive

▲ FIGURE 19-25 Myosin-dependent mechanisms for regulating smooth muscle contraction. (a) In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chains by Ca2+-dependent myosin LC kinase activates contraction. At Ca2+ concentrations <10—6M, the myosin LC kinase is inactive, and a myosin LC phosphatase, which is not

Myosin LC phosphatase - P;

Inactive

Phosphatase

Active

Myosin LC phosphatase

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