Multiple SREBPs Regulate Expression of Numerous Lipid Metabolizing Proteins

Under some circumstances (e.g., during cell growth), cells need an increased supply of all the essential membrane lipids and their fatty acid precursors (coordinate regulation). But

Citrate

ATP-citrate lyase

Citrate

ATP-citrate lyase

Acetyl CoA

Acetate

/Acetyl-CoA synthetase

Acetyl CoA

Acetate

/Acetyl-CoA synthetase

Malonyl CoA

Acetoacetyl CoA HMG-CoA synthase v

HMG CoA HMG-CoA reductase

Mevalonate

Mevalonate kinase Phosphomevalonate kinase Mevalonate PP decarboxylase GPP synthase IPP isomerase FPP synthase Squalene synthase

Malonyl CoA

Your Heart and Nutrition

Your Heart and Nutrition

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