Km

SbHS

▲ EXPERIMENTAL FIGURE 4-30 Eukaryotic mRNA forms a circular structure owing to interactions of three proteins.

In the presence of purified poly(A)-blndlng protein I (PABPI), eIF4E, and eIF4G, eukaryotic mRNAs form circular structures, visible in this force-field electron micrograph. In these structures, protein-protein and protein-mRNA interactions form a bridge between the 5' and 3' ends of the mRNA as diagrammed in Figure 4-31. [Courtesy of A. Sachs.]

M FIGURE 4-31 Model of protein synthesis on circular polysomes and recycling of ribosomal subunits. Multiple individual ribosomes can simultaneously translate a eukaryotic mRNA, shown here in circular form stabilized by interactions between proteins bound at the 3' and 5' ends. When a ribosome completes translation and dissociates from the 3' end, the separated subunits can rapidly find the nearby 5' cap (m7G) and initiate another round of synthesis.

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