▲ EXPERIMENTAL FIGURE 4-30 Eukaryotic mRNA forms a circular structure owing to interactions of three proteins.

In the presence of purified poly(A)-blndlng protein I (PABPI), eIF4E, and eIF4G, eukaryotic mRNAs form circular structures, visible in this force-field electron micrograph. In these structures, protein-protein and protein-mRNA interactions form a bridge between the 5' and 3' ends of the mRNA as diagrammed in Figure 4-31. [Courtesy of A. Sachs.]

M FIGURE 4-31 Model of protein synthesis on circular polysomes and recycling of ribosomal subunits. Multiple individual ribosomes can simultaneously translate a eukaryotic mRNA, shown here in circular form stabilized by interactions between proteins bound at the 3' and 5' ends. When a ribosome completes translation and dissociates from the 3' end, the separated subunits can rapidly find the nearby 5' cap (m7G) and initiate another round of synthesis.

Your Heart and Nutrition

Your Heart and Nutrition

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