Key Concepts Of Section

Nongated Ion Channels and the Resting Membrane Potential

■ An inside-negative electric potential (voltage) of 50-70 mV exists across the plasma membrane of all cells.

■ In animal cells, the membrane potential is generated primarily by movement of cytosolic K+ ions through resting

Ion concentration gradient

Membrane electric potential

Inside 12 mM Na+

Outside 145 mM Na+

Inside

Outside +

Outside +

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