Key Concepts Of Section 166

Sorting of Peroxisomal Proteins

■ All peroxisomal proteins are synthesized on cytosolic ribosomes and incorporated into the organelle post-translationally.

■ Most peroxisomal matrix proteins contain a C-terminal PTS1 targeting sequence; a few have an N-terminal PTS2 targeting sequence. Neither targeting sequence is cleaved after import.

■ All proteins destined for the peroxisomal matrix bind to a cytosolic receptor, which differs for PTS1- and PTS2-

Precursor membrane

Precursor membrane

Peroxisomal membrane proteins

Pex19

Peroxisomal membrane proteins

Pex19

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