Key Concepts Of Section 147

Down-Modulation of Receptor Signaling

■ Endocytosis of receptor-hormone complexes and their degradation in lysosomes is a principal way of reducing the number of receptor tyrosine kinases and cytokine receptors on the cell surface, thus decreasing the sensitivity of cells to many peptide hormones.

■ Bone resorption is triggered by binding of RANKL on osteoblasts to its receptor, RANK, on osteoclasts. RANKL/RANK signaling promotes tight adhesion of os-teoclasts to bone and secretion of a bone-dissolving mixture of HCl and proteases by osteoclasts (see Figure 14-31).

■ Osteoprotegerin, a decoy receptor for RANKL, inhibits osteoclast activation and bone resorption.

■ The extracellular domains of many cell-surface receptors can be produced by recombinant DNA techniques and have potential as therapeutic decoy receptors. Already in use is such a decoy receptor for TNF-a, which binds excess TNF-a associated with rheumatoid arthritis and other inflammatory diseases.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment