Key Concepts Of Section 136

Activation of Gene Transcription by G Protein-Coupled Receptors

■ Activation of phospholipase C by receptors coupled to Go or Gq proteins releases the Tubby transcription factor, which is bound to PIP2 embedded in the plasma membrane of resting cells (see Figure 13-31).

■ Signal-induced activation of protein kinase A (PKA) often leads to phosphorylation of CREB protein, which together with the CBP/300 co-activator stimulates transcription of many target genes (see Figure 13-32).

■ The GPCR-arrestin complex activates several cytosolic kinases, initiating cascades that lead to transcriptional activation of many genes controlling cell growth.

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