Key Concepts Of Section 136

Activation of Gene Transcription by G Protein-Coupled Receptors

■ Activation of phospholipase C by receptors coupled to Go or Gq proteins releases the Tubby transcription factor, which is bound to PIP2 embedded in the plasma membrane of resting cells (see Figure 13-31).

■ Signal-induced activation of protein kinase A (PKA) often leads to phosphorylation of CREB protein, which together with the CBP/300 co-activator stimulates transcription of many target genes (see Figure 13-32).

■ The GPCR-arrestin complex activates several cytosolic kinases, initiating cascades that lead to transcriptional activation of many genes controlling cell growth.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment