Key Concepts Of Section 122

Regulation of Pre-mRNA Processing

■ Because of alternative splicing of primary transcripts and cleavage at different poly(A) sites, different mRNAs may be expressed from the same gene in different cell types or at different developmental stages (see Figure 12-14).

■ Alternative splicing can be regulated by RNA-binding proteins that bind to specific sequences near regulated apoB gene apoB mRNA

apoB gene

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