Info

specific enhancers and promoter-proximal regions that regulate additional genes expressed only in hepatocytes contain binding sites for other specific combinations of transcription factors found only in these cells, together with those expressed unbiquitously.

(a) Hybrid proteins

DNA-binding Bait domain domain

Bait hybrid

Fish domain

Activation domain

Fish domain

Fish hybrid

Fish hybrid

(b) Transcriptional activation by hybrid proteins in yeast

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