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► FIGURE 3-23 Motor protein-dependent movement of cargo. The head domains of myosin, dynein, and kinesin motor proteins bind to a cytoskeletal fiber (microfilaments or microtubules), and the tail domain attaches to one of various types of cargo—in this case, a membrane-limited vesicle. Hydrolysis of ATP in the head domain causes the head domain to "walk" along the track in one direction by a repeating cycle of conformational changes.

(a) Myosin II Head Neck

Tail

Regulatory light chain

(a) Myosin II Head Neck

Tail

Regulatory light chain

Essential light chain

Heavy chains

Essential light chain

Heavy chains

(b) Head domain

Actin-binding , site '

(b) Head domain

Heavy chain

Essential light chain

Regulatory light chain

Heavy chain

Essential light chain

Regulatory light chain

▲ FIGURE 3-24 Structure of myosin II. (a) Myosin II is a dimeric protein composed of two identical heavy chains (white) and four light chains (blue and green). Each of the head domains transduces the energy from ATP hydrolysis into movement. Two light chains are associated with the neck domain of each heavy chain. The coiled-coil sequence of the tail domain organizes myosin II into a dimer. (b) Three-dimensional model of a single

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