Info

bicoid mRNA depends on its 3'-untranslated end and three maternally derived proteins. Embryos produced by female flies that are homozygous for bicoid mutations lack anterior body parts, attesting to the importance of Bicoid protein in specifying anterior cell fates.

Bicoid protein, a homeodomain-type transcription factor, activates expression of certain anterior-specific genes discussed later. In the syncytial fly embryo, Bicoid protein spreads through the common cytoplasm away from the an-

Copies of Bicoid protein bicoid gene gradient in in mother embryo

Promoter

Expression pattern

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High-

Low-

affinity

affinity

Bicoid-

Bicoid-

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binding

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