Info

Bloom's syndrome

Repair of double-strand breaks by homologous recombination

Mild alkylating agents

Carcinomas, leukemias, lymphomas

Photosensitivity, facial telangiectases, chromosome alterations

Fanconi anemia

Repair of double-strand breaks by homologous recombination

DNA cross-linking agents, reactive oxidant chemicals

Acute myeloid leukemia, squamous-cell carcinomas

Developmental abnormalities including infertility and deformities of the skeleton; anemia

Hereditary breast cancer, BRCA-1 and BRCA-2 deficiency

Repair of double-strand breaks by homologous recombination

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