Info

APC-Cdc20/ proteasome degrades securin

APC-Cdc20/ proteasome degrades securin

Metaphase

Anaphase

APC-Cdh1/proteasome degrades mitotic cyclins

Anaphase

Metaphase if

Mitotic cyclin-CDK

Mitotic cyclin-CDK activates early mitotic events

Telophase and cytokinesis

DNA pre-replication complexes assemble at origins

^cyclin-CDK

S-phase cyclin-CDK B activates pre-replication complexes

S-phase i-CDK

DNA pre-replication complexes assemble at origins

^cyclin-CDK

Q G1 cyclin-CDK inactivates Cdh1

Q G1 cyclin-CDK activates expression of S-phase cyclin CDK components

Q G1 cyclin-CDK phosphorylates S-phase inhibitor

(jnhibitoA)

S-phase cyclin-CDK

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