0.24 x 101
0.24 x 102
0.24 x 103 kcal/mol formed and broken at room temperature. Although these interactions are weak and have a transient existence at physiological temperatures (25-37 °C), multiple noncova-lent interactions can act together to produce highly stable and specific associations between different parts of a large molecule or between different macromolecules. We first review the four main types of noncovalent interactions and then consider their role in the binding of biomolecules to one another and to other molecules.
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