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Philadelphia chromosome

Philadelphia chromosome der (22)

▲ EXPERIMENTAL FIGURE 10-29 Chromosomal translocations can be analyzed using banding patterns and multicolor FISH. Characteristic chromosomal translocations are associated with certain genetic disorders and specific types of cancers. For example, in nearly all patients with chronic myelogenous leukemia, the leukemic cells contain the Philadelphia chromosome, a shortened chromosome 22 [der

(22)], and an abnormally long chromosome 9 [der (9)]. These result from a translocation between normal chromosomes 9 and 22. This translocation can be detected by classical banding analysis (a) and by multicolor FISH (b). [Part (a) from J. Kuby, 1997, Immunology, 3d ed., W. H. Freeman and Company, p. 578; part (b) courtesy of J. Rowley and R. Espinosa.]

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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