Cnn

Outward-facing conformation

▲ FIGURE 7-21 Operational model for the two-Na+/one-glucose symporter. Simultaneous binding of Na+ and glucose to the conformation with outward-facing binding sites (step Ml) generates a second conformation with inward-facing sites (step 12). Dissociation of the bound Na+ and glucose into the cytosol (step |3| ) allows the protein to revert to Its original outward-facing conformation (step |4|), ready to transport additional substrate. [See M. Panayotova-Heiermann et al., 1997, J. Biol. Chem. 272:20324, for details on the structure and function of this and related transporters.]

Was this article helpful?

0 0
Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook


Post a comment