▲ FIGURE 7-21 Operational model for the two-Na+/one-glucose symporter. Simultaneous binding of Na+ and glucose to the conformation with outward-facing binding sites (step Ml) generates a second conformation with inward-facing sites (step 12). Dissociation of the bound Na+ and glucose into the cytosol (step |3| ) allows the protein to revert to Its original outward-facing conformation (step |4|), ready to transport additional substrate. [See M. Panayotova-Heiermann et al., 1997, J. Biol. Chem. 272:20324, for details on the structure and function of this and related transporters.]
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