Protein Coupled Receptors That Activate or Inhibit Adenylyl Cyclase

We now turn our attention to the very large group of cell-surface receptors that are coupled to signal-transducing trimeric G proteins. All G protein-coupled receptors

▲ FIGURE 13-10 Schematic diagram of the general structure of G protein-coupled receptors. All receptors of this type have the same orientation in the membrane and contain seven transmembrane a-helical regions (H1-H7), four extracellular segments (E1-E4), and four cytosolic segments (C1-C4). The carboxyl-terminal segment (C4), the C3 loop, and, in some receptors, also the C2 loop are involved in interactions with a coupled trimeric G protein.

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