Fak

Fyn Shc

Growth factors (e.g., TGFa)

Grb2 SOS

p16 i

Cycl D:CDK4 Cycl D:CDK4

EiFe

Antigrowth factors (e.g., TGFP)

Cycl E:CDK2 p21

Cycl E:CDK2 p21

1 PKC Mos MKK

-►Ras—► Raf—► MEK—► MAPK—KMAPK^EIK—>-Fos-

G-prot

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