Eiiia

Fibroblast fibronectin mRNA

Hepatocyte fibronectin mRNA

▲ FIGURE 4-15 Cell type-specific splicing of fibronectin pre-mRNA in fibroblasts and hepatocytes. The =75-kb fibronectin gene (top) contains multiple exons. The EIIIB and EIIIA exons (green) encode binding domains for specific proteins on the surface of fibroblasts. The fibronectin mRNA produced in

fibroblasts includes the EIIIA and EIIIB exons, whereas these exons are spliced out of fibronectin mRNA in hepatocytes. In this diagram, introns (black lines) are not drawn to scale; most of them are much longer than any of the exons.

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