Dna

General transcription factors o O

Mediator complex

-mmmmmm ünfai

Promoter

-mmmmmm ünfai

Promoter

Transcription preinitiation complex

Transcription preinitiation complex

▲ FIGURE 3-9 The mRNA transcription-initiation machinery.

The core RNA polymerase, general transcription factors, a mediator complex containing about 20 subunits, and other protein complexes not depicted here assemble at a promoter in DNA. The polymerase carries out transcription of DNA; the associated proteins are required for initial binding of polymerase to a specific promoter, thereby initiating transcription.

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