Contraction of Skeletal Muscle Is Regulated by Ca2 and Actin Binding Proteins

Like many cellular processes, skeletal muscle contraction is initiated by an increase in the cytosolic Ca2+ concentration. As described in Chapter 7, the Ca2+ concentration of the cytosol is normally kept low, below 0.1 ^M. In nonmuscle cells, Ca2+ ATPases in the plasma membrane maintain this low concentration. In contrast, in skeletal muscle cells, a m O

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