ABC Proteins Mediate Cellular Export of Phospholipids and Cholesterol

Human Bile Acids

The export of phospholipids and cholesterol can be simultaneous owing to the activity of various members of the ABC superfamily (see Table 18-2). The best-understood example of this phenomenon is in the formation of bile, an aqueous fluid containing phospholipids, cholesterol, and bile acids, which are derived from cholesterol. After export from liver cells, phospholipids, cholesterol, and bile acids form water-soluble micelles in the bile, which is delivered through ducts to the gallbladder,...

Viruses Are the Ultimate Parasites

Virus-caused diseases are numerous and all too familiar chicken pox, influenza, some types of pneumonia, polio, measles, rabies, hepatitis, the common cold, and many others. Smallpox, once a worldwide scourge, was eradicated by a decade-long global immunization effort beginning in the mid-1960s. Viral infections in plants (e.g., dwarf mosaic virus in corn) have a major economic impact on crop production. Planting of virus-resistant varieties, developed by traditional breeding methods and more...

Overview Of Changes In Cells In Cancer

Overview Changes Cells Cancer

23.1 Tumor Cells and the Onset of Cancer 23.2 The Genetic Basis of Cancer 23.3 Oncogenic Mutations in Growth-Promoting Proteins 23.4 Mutations Causing Loss of Growth-Inhibiting and Cell-Cycle Controls 23.5 The Role of Carcinogens and DNA Repair in Cancer FIGURE 23-1 Overview of changes in cells that cause cancer. During carcinogenesis, six fundamental cellular properties are altered, as shown here, to give rise to the complete, most destructive cancer phenotype. Less dangerous tumors arise when...