Ecogenetics The Study of Gene Environment Interactions Daniel W Nebert Amy L Roe PhD

7 Classification of Ecogenetic Differences

Various colleagues have differing opinions as to what might be included as an "ecogenetics difference," because some of these are commonly considered as "inborn errors of metabolism." Table 7.3 lists the classification we will use here, based on categories of less enzyme or defective protein, increased resistance (usually a receptor-mediated mechanism), altered response due to differences in enzyme induction, abnormal metal distribution, and "other" disorders of unknown etiology. The examples that are detailed below are selected from Table 7.3, and in the order in which they appear on this list. (For further discussion on many of these other ecogenetic differences, the reader is referred to Refs. 3, 4, 8, and 11-24).

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