Use of Toxicological Data in Evaluating Chemical Safety Gloria Rachamin PhD

Dose Response Curve Noael Loael

5 Characterization of Dose-Response Relationships The quantitative relationships between dose and the incidence of adverse response (see Appendix 1) provide the basis for evaluating chemical hazard and the derivation of exposure limits. The approach used to assess the dose-response relationship depends on whether the chemical produces threshold or nonthreshold end points (19, 20). 5.1 Threshold and Nonthreshold Effects A threshold dose-response relationship is used to evaluate chemicals that...