Uses in Urology

Propantheline (Pro-Banthine), oxybutynin, dicyclo-mine, and several other agents have been used for uninhibited bladder syndrome, bladder spasm, enuresis, and urge incontinence. Tolterodine (Detrol), a nonselective muscarinic antagonist, exhibits functional specificity for blocking muscarinic receptors in the bladder, with fewer side effects than oxybutynin. However, total prevention of involuntary bladder contractions is difficult to achieve. The participation of noncholinergic, nonadren-ergic nerves in bladder contraction may explain this apparent resistance to muscarinic blocking agents.

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