Toxicity

Digitalis toxicity includes nausea, vomiting, anorexia, fatigue, and a characteristic visual disturbance (green-yellow halos around bright objects). Cardiac toxicities have included tachyarrhythmias and bradyarrhythmias, including supraventricular and ventricular tachycardia and atrioventricular (A-V) block. The most classic (but not most frequent) manifestations of digitalis toxicity include atrial tachycardia with A-V block. Treatment for digitalis toxicity ranges from mild cases that respond to simply stopping the drug to the use of antidigitalis antibodies in life-threatening situations. The availability of a radioimmunoassay for digitalis levels and antidigitalis antibodies, useful in reversing digitalis's actions, have minimized the frequency of fatal toxicity.

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