Tissue Specificity Of Human Drug Metabolism Enzymes

Though most drug metabolism enzymes reside in the liver, other organs may also play an important role. All of the enzymes previously mentioned are found in the human liver, but other tissues and organs may have some complement of these enzymes. CYP3A4 and CYP3A5 have been found in the human gut and can contribute to substantial metabolism of orally administered drugs, even before the compound reaches the liver. For example, CYP3A4 may play a substantial role in the low bioavailability of cyclosporine. Drug-metabolizing enzymes have also been found in measurable quantities in the kidney, brain, placenta, skin, and lungs.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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