The Therapeutic Objectives In The Use Of Antianginal Drugs

The major therapeutic objectives in the treatment of angina are aimed at terminating or preventing an acute attack and increasing the patient's exercise capacity. These objectives can be achieved by reducing overall myocardial oxygen demand or by increasing oxygen supply to ischemic areas. A decrease in myocardial oxygen demand can be attained through use of the organic nitrates, calcium entry blockers, and p-adrenoceptor blocking agents. Increases in myocardial oxygen supply are more difficult to achieve, especially when coronary blood vessels are partially or totally obstructed. However, redistribution of blood flow to the subendocardium of

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