The Sulfonylurea Receptor

The sulfonylurea receptor was identified as an adeno-sine triphosphate (ATP) sensitive potassium (KATP) channel that is present on the ¡-cell membrane surface. Closure of these KATP channels causes ¡-cell membrane

TABLE 67.4 Pharmacokinetic Properties of Oral Hypoglycemic Drugs

Drug

Half-Life (hr)

Duration of Action (hr)

Activity of Metabolites

Sulfonylureas

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