Diethylstilbestrol (DES) was once given to prevent spontaneous abortion, but it no longer has such a medical indication. There is a 0.01 to 0.1% incidence of a rare vaginal and cervical clear cell adenocarcinoma among the daughters of mothers who received DES during their first trimester of pregnancy. An increased cancer incidence in male offspring of mothers who had received DES has also been noted.

Progestins may be teratogenic during the first trimester of pregnancy. Therefore, if pregnancy is suspected, oral contraceptive use should not be initiated or use should be stopped promptly.

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