Table 551

Cancers with 40 to 80 Percent Cure Rates

Type of Cancer



Acute lymphocytic leukemia

Burkitt's sarcoma

Ewing's sarcoma



Wilms' tumor

Hodgkin's disease

Non-Hodgkin's disease

Trophoblastic choriocarcinoma

Testicular and ovarian germ cell cancers classification divides the anticancer drugs into three categories:

1. Class 1 agents (e.g., radiation, mechloreth-amine, and carmustine) exert their cytotoxicity in a nonspecific (i.e., non-proliferation dependent) manner. They kill both normal and malignant cells to the same extent.

2. Class 2 agents are phase specific and reach a plateau in cell kill with increasing dosages. Only a certain proportion of cells are sensitive to the toxic effects of these drugs. For example, hydroxyurea and cytarabine kill only cells in the S-phase. Similarly, bleomycin is most toxic to cells in G2- and early M-phases. Because they affect only a small fraction of the cell population at any one time, it has been suggested that these drugs should be given either by continuous infusion or in frequent small doses. Such a dosage regimen would increase the number of tumor cells exposed to the drug during the sensitive phase of their cell cycle.

3. Class 3 agents kill proliferating cells in preference to resting cells. It has been recommended

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