Table 551

Cancers with 40 to 80 Percent Cure Rates

Type of Cancer

Childhood

Adult

Acute lymphocytic leukemia

Burkitt's sarcoma

Ewing's sarcoma

Retinoblastoma

Rhabdomyosarcoma

Wilms' tumor

Hodgkin's disease

Non-Hodgkin's disease

Trophoblastic choriocarcinoma

Testicular and ovarian germ cell cancers classification divides the anticancer drugs into three categories:

1. Class 1 agents (e.g., radiation, mechloreth-amine, and carmustine) exert their cytotoxicity in a nonspecific (i.e., non-proliferation dependent) manner. They kill both normal and malignant cells to the same extent.

2. Class 2 agents are phase specific and reach a plateau in cell kill with increasing dosages. Only a certain proportion of cells are sensitive to the toxic effects of these drugs. For example, hydroxyurea and cytarabine kill only cells in the S-phase. Similarly, bleomycin is most toxic to cells in G2- and early M-phases. Because they affect only a small fraction of the cell population at any one time, it has been suggested that these drugs should be given either by continuous infusion or in frequent small doses. Such a dosage regimen would increase the number of tumor cells exposed to the drug during the sensitive phase of their cell cycle.

3. Class 3 agents kill proliferating cells in preference to resting cells. It has been recommended

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment