Minimum Alveolar Concentration in Oxygena
"Expressed as the percent of lung gases that are anesthetic gas at 1 atm.
»MAC value greater than 100 indicates that hyperbaric conditions are required to produce anesthesia. Adapted with permission from Eger EI II (ed.). Anesthetic Uptake and Action. Baltimore: Williams & Wilkins, 1974:5;Eger EI. Isoflurane: A review. Anesthesiology 1981;55:559.
appear to have an additive effect on the level of unconsciousness. Therefore, when a combination of inhala-tional agents is used (e.g., N2O with halothane), MAC values for the individual agents can be reduced appropriately. In this regard, an acceptable anesthetic maintenance tension for N2O and halothane in the inspired air may be 40% and 0.5%, respectively.
The MAC requirement also is reduced by the coad-ministration of other CNS depressants, such as barbiturates or opioid analgesics. CNS stimulants, such as amphetamine, may elevate the partial pressure needed for anesthesia.
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