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Answer: You decide that a metabolite of imipenem is responsible for the sudden toxicity. You add a second drug, cilastatin, to the patient's regimen. Coadministration of cilastatin inhibits renal dipeptidase, the enzyme responsible for the metabolism of imipenem. This prevents the formation of the toxic metabolite and decreases the clearance of imipenem. The side effect disappears within 12 hours and the patient recovers from the infection.
Case Study A Beneficial Example of Pharmacokinetics
Synthetic Organic Antimicrobials: Sulfonamides, Trimethoprim, Nitrofurans, Quinolones, Methenamine
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