Supplemental Reading

Fung HL and Bauer JA. Mechanisms of nitrate tolerance. Cardiovasc Drug Ther 1994;8:489.

Knight CJ et al. Different effects of calcium antagonists, nitrates and beta blockers on platelet function: Possible importance for the treatment of unstable angina. Circulation 1997;95:125-132.

Kurz S et al. Evidence for a causal role of the renin-angiotensin system in nitrate tolerance. Circulation 1999;99:3181-3187.

Munzel T et al. Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production. J Am Coll Cardiol


Parker JD and Parker JO. Drug therapy: Nitrate therapy for stable angina pectoris. N Engl J Med 1998;338:520-531. Torfgard KE and Ahlner J. Mechanisms of action of nitrates. Cardiovasc Drug Ther 1994;8:701-717.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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