Structure Activity Relationships

Natural Corticosteroids

Within the basic structure of the steroid molecule (Fig. 60.4), a 4,5 double bond and a 3-ketone group are needed for typical steroid activity. A hydroxyl group on C11 is needed for glucocorticoid activity (cortico-sterone) but is not required for sodium-retaining activity (desoxycorticosterone). The addition of a hydroxyl group on C17, which converts corticosterone to cortisol, also increases glucocorticoid activity.

Synthetic Corticosteroids

The ultimate aim in altering the steroid molecule is to decrease sodium-retaining activity and to increase anti-inflammatory glucocorticoid activity.

Ring A

The addition of a double bond at the 1,2 position of cortisol or cortisone yields prednisone or prednisolone, respectively, and increases the ratio of carbohydrate to

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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