Structure and Mechanism of Action

Vancomycin (Vancocin) is a complex tricyclic glycopep-tide antibiotic produced by Streptomyces orientalis, while teicoplanin (Targocid) is derived from Actino-planes (Actinomyces) teichomyceticus. Teicoplanin has two major components: a phosphoglycolipid (A1) and five chlorine-containing glycopeptides (A2). It is available as an investigational drug.

The glycopeptides are inhibitors of cell wall synthesis. They bind to the terminal carboxyl group on the d-alanyl-d-alanine terminus of the N-acetylglucosamine-N-acetylmuramic acid peptide and prevent polymerization of the linear peptidoglycan by peptidoglycan synthase. They are bactericidal in vitro.

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