Structure and Mechanism of Action

Vancomycin (Vancocin) is a complex tricyclic glycopep-tide antibiotic produced by Streptomyces orientalis, while teicoplanin (Targocid) is derived from Actino-planes (Actinomyces) teichomyceticus. Teicoplanin has two major components: a phosphoglycolipid (A1) and five chlorine-containing glycopeptides (A2). It is available as an investigational drug.

The glycopeptides are inhibitors of cell wall synthesis. They bind to the terminal carboxyl group on the d-alanyl-d-alanine terminus of the N-acetylglucosamine-N-acetylmuramic acid peptide and prevent polymerization of the linear peptidoglycan by peptidoglycan synthase. They are bactericidal in vitro.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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