Strabismus

Drug treatment of strabismus (turning of one or both eyes from the normal position) is largely limited to certain cases of accommodative esotropia (inward deviation). Long-acting anticholinesterase agents, such as echothiophate or demecarium, are employed to potentiate accommodation by blocking ACh hydrolysis at the ciliary muscle and decreasing the activity of extraocular muscles of convergence. This results in reduced accommodative convergence. The same side effects and precautions mentioned for the use of these drugs in glaucoma apply to the therapy of strabismus.

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