Amiodarone decreases the slope of phase 4 depolarization. The rate of spontaneous discharge of the sino-atrial node is increased by amiodarone as well as by its metabolite, desethylamiodarone. The depressant action of amiodarone on sinoatrial pacemaker function is, in addition to p-receptor blockade, related to an inhibition of the slow inward current carried by the calcium ion.
Amiodarone prolongs the action potential in atrial muscle and increases the absolute and effective refractory periods.
Amiodarone, like its major metabolite desethyl-amiodarone, increases A-V nodal conduction time and refractory period.
Was this article helpful?
Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.