Renin

Renin is an enzyme that is synthesized and stored in the renal juxtaglomerular apparatus and that catalyzes the formation of a decapeptide, angiotensin I, from a plasma protein substrate. Renin has a narrow substrate specificity that is limited to a single peptide bond in an-giotensinogen, a precursor of angiotensin I. Renin is considered to control the rate-limiting step in the ultimate production of angiotensin II. Control of renin secretion by the juxtaglomerular apparatus is important in determining the plasma renin concentration.

Liver

Kidney

Kidney

Liver

1 2 345678 9 10 Angiotensin I NH2-(Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu)-COOH
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