Renal Excretion

Although some drugs are excreted through extrarenal pathways, the kidney is the primary organ of removal for most drugs (Figure 4.2), especially for those that are water soluble and not volatile. The three principal processes that determine the urinary excretion of a drug are glomerular filtration, tubular secretion, and tubular reabsorption (mostly passive back-diffusion). Active

Afferent Arteriole Efferent Arteriole

Afferent Arteriole Efferent Arteriole

passive reabsorption

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