Phenylbutazone (Butazolidin) is metabolized to oxy-phenbutazone (Phlogistol), and both compounds have all of the activities associated with the NSAIDs. Their use is accompanied by serious adverse reactions, such as anemia, nephritis, renal failure or necrosis, and liver damage. Because of their toxicity, they are prescribed only for the treatment of pain associated with gout or phlebitis or as a last resort for other painful inflammatory diseases resistant to newer and less toxic treatments. Interactions with a large number of other drugs
(similar to those described for aspirin) occur, since phenylbutazone displaces several drugs from plasma protein binding sites.The drug is contraindicated in children and in the elderly with diminished renal function. The consequences of overdose occur slowly and can include liver damage, renal failure, and shock. There is no antidote for overdose. Supportive measures include ventilation, dialysis, and gastric lavage with activated charcoal, as well as the use of benzodiazepines to control convulsions.
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.