Potassium Perchlorate

The perchlorate ion of potassium perchlorate, KClO4, is a competitive inhibitor of thyroidal I~ transport via the Sodium Iodide Symporter (NIS).This drug can cause fatal aplastic anemia and gastric ulcers and is now rarely used. If administered with careful supervision, in limited low doses and for only brief periods, serious toxic effects can be avoided. The compound is especially effective in treating iodine-induced hyperthyroidism, which may occur, for example, in patients treated with the antiar-rhythmic compound amiodarone. Perchlorate ion can also be used in a diagnostic test of I~ incorporation into Tg, the so-called perchlorate discharge test.

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