Phenothiazine Derivatives

Phenothiazine derivatives, which include prochlorper-azine (Compazine) and promethazine (Phenergan), act at the CTZ by inhibiting dopaminergic transmission. They also decrease vomiting caused by gastric irritants, suggesting that they inhibit stimulation of peripheral vagal and sympathetic afferents. Sedation will frequently occur following their administration. Patients also may have problems with acute dystonic reactions, orthostatic hypotension, cholestatic hepatitis, and blood dyscrasias.

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