Phase 3 Late Phase of Repolarization

Termination of phase 2 of the action potential plateau occurs when time-dependent, voltage-dependent, and in-tracellular Ca++-dependent inactivation of ICa++ results in the unopposed repolarizing effects of the outward K+ currents. The combination of these effects results in rapid repolarization with a return to the hyperpolarized resting membrane potential. Pharmacological interventions that inhibit IK prolong the membrane action potential by de laying repolarization. Mutations in the genes encoding the various subtypes of IK inhibit proper channel function and result in the LQTS.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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