Phenothiazines are classified on the basis of their chemistry, pharmacological actions, and potency. Chemical classifications include the aliphatic (e.g., chlorproma-zine; Thorazine),piperidine (e.g., thioridazine;Mellaril), and piperazine subfamilies. The piperazine derivatives are generally more potent and pharmacologically selective than the others. The thioxanthenes (e.g., thio-thixene; Navane) are chemically related to the pheno-thiazines and have nearly equivalent potency. The butyrophenone haloperidol (Haldol) is structurally distinct from the two preceding groups, offering greater potency and fewer autonomic side effects. The dibenzo-diazepine clozapine (Clozaril) bears some structural resemblance to the phenothiazine group but causes little extrapyramidal toxicity. The benzisoxazole risperidone (Risperdal) is representative of many of the newer agents in having a unique structure relative to the older groups while retaining antipsychotic potency and a better side effect profile.
Was this article helpful?
This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.