Pharmacological Actions

A primary advantage of etomidate is its ability to preserve cardiovascular and respiratory stability; both cardiac output and diastolic pressure are well maintained. Use of etomidate may offer some advantage to the patient with compromised myocardial oxygen or blood supply or both, since it produces mild coronary vasodi-lation. Thus, coronary vascular resistance decreases with no change in perfusion pressure. Preservation of dia-stolic perfusion pressure may be particularly important when myocardial blood supply cannot be increased by autoregulation.

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